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Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease

Published pharmaceutical manufacturing standards exist specifically because the margin between "looks clean" and "is sterile" is the difference between a safe injection and a fever, abscess, or systemic infection

The 10 mg dose produced 19.5%

Vitamin B12 can be found naturally in foods